From the doc: http://wiki.nginx.org/ReadMoreAboutTcpNodelay
TCP_NODELAY is for a specific purpose; to disable the Nagle buffering
algorithm. It should only be set for applications that send frequent
bursts of information without getting an immediate response, where
delivery of data is required (the canonical example is mouse movements).
So my understanding for most web app, it should be disabled so we can
the “Nagle buffering algorithm”, only disable when you have special
like logging mouse movements as in the example?