How do others handle no-cache?

The browser can append to the request a ‘no-cache’ option and other
options. Firefox sets this if you do a refresh with the shift key down
(at least on the Mac).

I am considering expiring all of my fragments that are cached for that
particular request before proceeding with the request if no-cache has
been specified.

I was wondering what others are doing (if anything).

Thank you,
pedz