Expierence nGinx with Typo3 Caching

Hello Everybody,

Does anybody have expierence with nginx and typo3 caching?

I have a very strange problem with the caching on of our customers
sites. They made changes in typo3. On the first domain first.domain.de
the changes will take their effect. When the customer will make another
changes, then the nginx will show the old cache.

What is here the problem? Maybe the proxy_cache_key?

Best Regards,